Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses

<div>Effects of dietary electrophilic compounds on redox sensor Keap1. (1) Redox-sensing protein Keap1 is activated by intracellular oxidative stress or other electrophilic compounds, changing its conformation. (2) Keap1 releases transcription factor Nrf2 to translocate to the nucleus and upregulate the expression of a battery of antioxidant, anti-inflammatory, and cell protective genes including heme oxygenase-1 (Ho-1).</div>

Oxidative Medicine and Cellular Longevity

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Figure 2: Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses 

Figure 2 | Falcarinol Is a Potent Inducer of Heme Oxygenase-1 and Was More Effective than Sulforaphane in Attenuating Intestinal Inflammation at Diet-Achievable Doses 