Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 2

Research Article

Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

Figure 2

EX527 abolished HKL-induced cardioprotective effects on MI/R injury in type 1 diabetic rats. (a) Representative M-mode images by echocardiography. Echocardiographic assessment was performed after 72 h of reperfusion. (b) Left ventricular ejection fraction (LVEF). (c) Left ventricular fractional shortening (LVFS). (d) Serum CK activity. (e) Serum LDH activity. (f) Representative digital images of heart sections by Evans blue and triphenyltetrazolium chloride (TTC) double staining. (g) Myocardial infarct size. Data are presented as the mean ± SEM ( in each group). versus the T1D + sham group, versus the T1D + MI/R group, versus the T1D + MI/R + HKL group.

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