Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 4

Research Article

Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

Figure 4

EX527 abolished HKL-induced suppression on myocardial apoptosis in MI/R-injured diabetic myocardium. (a) Representative images of TUNEL staining (300x, bar = 100 μm). The apoptotic cells were detected by TUNEL (green), and the nuclei were detected by DAPI (blue). (b) Myocardial apoptotic index. (c) Representative blots. (d) Bcl-2/Bax ratio. (e) Cleaved caspase 3 expression. (f) Cytosolic cytochrome c expression. (g) Representative blots. (h) SIRT1 expression. (i) Relative SIRT1 activity. (j) Nrf2 nuclear translocation. Data are presented as the mean ± SEM ( in each group). versus the T1D + sham group, versus the T1D + MI/R group, versus the T1D + MI/R + HKL group.

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