Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 8

Research Article

Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway

Figure 8

SIRT1 acted as an upstream regulator of Nrf2 in mediating the cardioprotective actions of HKL. (a) Representative blots. (b) SIRT1 expression. (c) Nrf2 nuclear translocation. (d) SIRT1 immunofluorescent staining (×300, bar = 100 μm). Red fluorescence shows SIRT1 (row 1); blue fluorescence shows cell nuclei (row 2). (e) SIRT1 immunofluorescence intensity. (f) Relative SIRT1 activity. Data are presented as the mean ± SEM ( in each group). versus the HG group, versus the HG + SIR group, versus the HG + SIR + HKL group, versus the siSIRT1 + HG + SIR + HKL group.

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