TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance

Figure 4

Mitochondrial dynamic imbalance was increased in DCM mice after TLR4 activation. (a) Representative illustrations of transmission electron microscopy (TEM) showing the fragmentation of mitochondria in each group (×6000). (b) Representative illustrations of transmission electron microscopy (TEM) showing the ultrastructural changes of mitochondria in each group (×11,000). (c-d) Graphs summarize the amount of mitochondria per area and average mitochondrial size of mitochondria (). (e) Representative images of mitochondrial morphology in H9C2. (f) Quantification of four independent experiments for fragmented mitochondria (). Bar = 2 μm. , versus sham; , versus control; versus control; versus control (c-d); , , versus control (f).

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