Mesenchymal Stromal Cell Therapy for Pancreatitis: A Systematic Review

Table 2

Summary of studies addressed MSCs in chronic pancreatitis. hFMMSCs: human fetal membrane mesenchymal stromal cells; rBM-MSCs: rat bone marrow mesenchymal stromal cell; rUCMSCs: rat umbilical cord mesenchymal stromal cells; PBS: phosphate buffer saline; SD rats: Sprague Dawley rats; N/A: not applicable

Author	Method of induction of pancreatitis	Source of MSCs	Dose of infused MSCs	Route of MSC infusion	Timeline of MSC therapy		Specific treatment of MSCs	Outcome
					Infusion; time point	Scarification time point		Pancreatic fibrosis	Mechanism of action of infused MSCs
K et al., 2016	Dibutyltin dichloride	hFMMSCs	1 × 10^6 cells in 200 μl PBS	Penile vein of SD rats	On day 5	Day 14	N/A	Decreased	(i) Immunomodulatory effect; (ii) Inhibition of activation of pancreatic satellite cells
Qin et al., [59]	N/A	rBM-MSCs	N/A	N/A	Group 1: 4 hrs. before chronic pancreatitis; Group 2: during; chronic pancreatitis; Group 3: 4 hrs. after chronic pancreatitis	N/A	BM-MSCs were transfected with IkBαM		(i) Immunomodulatory effect; (ii) Antiapoptotic effect: reduced acinar cell apoptosis; (iii) Inhibition of activation of pancreatic satellite cells
Zhou et al., [60]	Dibutyltin dichloride	rUCMSCs	1 × 10^6 cells/ml	Jugular vein of SD rats	On day 5	On days 14 and 28	rUCMSCs injected through jugular vein		(i) Immunomodulatory effect; (ii) Antiapoptotic effect: reduced acinar cell apoptosis; (iii) Inhibition of activation of pancreatic satellite cells