3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

Figure 6

DDO7232 downregulated the inflammatory factors in the sera of mice and attenuated DSS-induced damage. The levels of various inflammatory cytokines in serum of C57BL/6 female mice were measured, including IL-6, MCP-1, IL-1β, IFN-γ, and TNF-α. Mice were injected intraperitoneally with different doses of DDO7232 (10 mg/kg, 50 mg/kg, and 100 mg/kg, respectively). DSS (2%) was used as a stimulant, and olsalazine (50 mg/kg) was used as a positive control. The ratios of IL-6, MCP-1, IL-1β, IFN-γ, and TNF-α in serum were determined by ELISA. Data are expressed as (). Differences were considered statistically significant at .