3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

Figure 7

DDO7232 alleviated the pathological symptoms of DSS-treated chronic ulcerative colitis. The mouse model was divided into six groups by random assignment (ten mice per group). Mice in the control group were treated with regular drinking water. The DSS-induced group was treated with 2% w/v DSS in drinking water. DSS (treated with 2% w/v DSS in drinking water) + various concentrations of DDO7232 (10 mg/kg, 50 mg/kg, and 100 mg/kg, resp., using direct intraperitoneal injection) groups were used to determine the effects of DDO7232 on this mouse model of UC. DSS (treated with 2% w/v DSS in drinking water) + olsalazine (50 mg/kg direct intraperitoneal injection) group was set as a positive control. (a) Body weight changes of the mice in all six experimental groups (). (b) A comparison of colon lengths of all six experimental groups on day 55 (). (c) Representative histological images of distal colon sections stained with hematoxylin and eosin (H&E) to evaluate the anti-inflammatory effect of DDO7232 (). Magnification: ×100.

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