A Novel Mechanism of Mesenchymal Stromal Cell-Mediated Protection against Sepsis: Restricting Inflammasome Activation in Macrophages by Increasing Mitophagy and Decreasing Mitochondrial ROS

Figure 8

Proposed scheme for the mechanism of mesenchymal stromal cell-mediated protection against sepsis. A summary of our current hypothesis about the mechanisms that underlie the interactions between BMSCs and BMDMs in the CLP sepsis model. BMSCs negatively regulate the NLRP3 inflammasome in BMDMs primarily by increasing mitophagy of BMDMs in response to crosstalk with activated BMDMs and thus by decreasing mitochondrial ROS.