Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation

Figure 2

Stevia prevents chronic liver inflammation, necrosis, and cholestasis in chronic liver damage. The representative hematoxylin and eosin staining of liver sections obtained from the control (a), CCl₄ (b), CCl₄ + stevia (c), and stevia-treated rats (d). Histograms depict the liver (e), body (f), and body : liver weight ratio (g), alanine aminotransferase (ALT) (h), alkaline phosphatase (AP) (i), and gamma-glutamyl transpeptidase (γ-GTP) (j) serum activities, and liver glycogen content (k), total (l), and unconjugated serum bilirubin (m) levels. Each bar represents the mean value of experiments performed in duplicate ± SE (). versus the control group; versus the CCl₄ group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)

(m)