ATM Induces Cell Death with Autophagy in Response to H₂O₂ Specifically in Caenorhabditis elegans Nondividing Cells

Figure 1

atm-1(tm5027) worms were sensitive to several DNA-damaging agents. (a–c) Synchronized L1 larvae of N2 (white bar or black diamond) and atm-1(tm5027) (gray bar and white bar) were irradiated with (a) 100 Gy of -rays or (b) 15 J/m² UVC light or underwent time-course treatment with (c) 0.2 mg/ml MMC at 20°C. After treatments, the worms were cultured for 4 days and we calculated the ratio of adult worms/transferred L1 worms. All data are mean ± SD and means significantly different by Student’s -test (). The photograph of a worm was obtained from TogoTV (© 2016 DBCLS TogoTV).