Oxidative Stress in Women Treated with Atosiban for Impending Preterm Birth

Table 2

Oxidative and antioxidative parameters in plasma and serum before and after 48 hours of continuous administration of tocolytic therapy with Atosiban.

Treatment with Atosiban
Variable	0 hours	48 hours	value
TOS (μmol/L)	18.217 ± 16.093	30.442 ± 30.578	0.0011^a
TAS (mmol/L)	0.936 ± 0.360	0.582 ± 0.305	<0.0001^a
OSI (arbitrary units)	0.022 ± 0.022	0.115 ± 0.395	<0.001^a
Carbonyl groups (μmol/L)	65.358 ± 31.322	97.982 ± 38.047	<0.001^b
Thiol groups (μmol/L)	512.023 ± 121.162	516.240 ± 111.886	0.806^a
3-Nitrotyrosine (nM)	40.8 ± 45.7	50.5 ± 44.7	0.210^a

Data are presented as mean value and standard deviation. TOS: total oxidant status; TAS: total antioxidant status; OSI: oxidative stress index, ^aWilcoxon’s test for paired samples, ^ba paired Student -test.