The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

Figure 1

Synthesis and catabolism of H₂S. AAT: aspartate aminotransferase; CDO: cysteine dioxygenase; CSE: cystathionine γ-lyase; HDH: hypotaurine dehydrogenase; GCS: γ-glutamyl cysteine synthase; GS: glutathione synthase; MAT: methionine adenosyltransferase; MS: methionine synthase; S0: elemental sulfur; SAM: S-adenosylmethionine; THF: tetrahydrofolate; TSST: thiosulfate sulfurtransferase; CBS: cystathionine β-synthase; CSD: sulfinate decarboxylase; DAO: D-amino acid oxidase; H₂S: hydrogen sulfide; GNMT: glycine N-methyltransferase; GSH: glutathione; 3MST: 3-mercaptopyruvate sulfide transferase; MTHFR: methylenetetrahydrofolate reductase; SAH: S-adenosylhomocysteine; SO: sulfite oxidase; TSR: thiosulfate reductase; TSMT: thiol S-methyltransferase.