The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

Table 2

Characteristics of H₂S-producing enzymes.

	Cystathionine γ-lyase (CSE)	Cystathionine β-synthase (CBS)
Localization	Liver, heart, vessels, kidney, brain, adipose, small intestine, stomach, uterus, placenta, and pancreatic islets	Brain, liver, kidney and ileum, uterus, placenta, and pancreatic islets
Activators	Pyridoxal 5-phosphate	Pyridoxal 5-phosphate, S-adenosyl-L-methionine, and Ca^2+/calmodulin
Inhibitors	D,L-propargylglycine, β-cyano-L-alanine	Hydroxylamine, aminooxyacetate
Functional roles	H2S production in the liver and smooth muscle	H2S production in the brain and nervous system