Research Article
Comparison of Pulmonary and Systemic NO- and PGI2-Dependent Endothelial Function in Diabetic Mice
Figure 3
NO- and PGI2-dependent function in the diabetic isolated lungs. (a) Impaired NO-dependent hypoxic pulmonary vasoconstriction response after L-NAME in the lungs of the diabetic mice (control , diabetes ). (b, c) Lack of change in basal production of nitrite and nitrate and (d, e) impaired capacity to cumulative production of nitrite but not nitrate in effluents from the isolated, perfused lungs of the diabetic mice (control , diabetes ). (f) Increased COX-2-dependent prostacyclin production in effluents from the isolated, perfused lungs and effects of a COX-2 inhibitor (DuP-697, 1 μM, control , diabetes ). Data are presented as the means ± SEM. .
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