Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice

<div>Passive avoidance test with young, aged, and long-term POS-treated mice. On day one, mice receive an electric shock (0.5 mA) and time is recorded when the mouse needs to enter into the dark chamber; 24 h after the first testing period, the test is repeated and time is recorded when the mouse needs to reenter the dark chamber; <svg height="9.92533pt" id="M56" style="vertical-align:-1.57651pt" version="1.1" viewbox="-0.0498162 -8.34882 37.0753 9.92533" width="37.0753pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,21.421,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g><g transform="matrix(.013,0,0,-0.013,27.661,0)"><path d="M137 343C167 482 260 545 321 574C357 591 397 603 429 609L423 641C382 634 335 622 295 608C189 570 37 457 37 238C37 84 125 -12 242 -12C362 -12 447 89 447 209C447 311 374 393 267 393C247 393 226 386 204 376L137 343ZM227 337C318 337 361 256 361 173C361 105 336 22 258 22C176 22 126 120 126 240C126 266 127 291 132 310C155 323 189 337 227 337Z"></path></g><g transform="matrix(.013,0,0,-0.013,33.901,0)"><path d="M114 412C81 412 58 388 58 355C58 321 81 297 113 297S169 321 169 355C169 388 145 412 114 412ZM95 130C70 130 46 114 46 88C46 72 54 65 59 64C93 56 121 33 121 -3C121 -41 93 -68 45 -88L56 -118C117 -99 186 -56 186 22C186 91 131 130 95 130Z"></path></g></svg> mean ± SEM.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice 