Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice

Table 5

Activities of the respiratory chain complexes I and IV in isolated mitochondria of young, aged, and aged mice fed with POS determined using an Oxygraph-2k; , mean ± SEM. GPx-1 was measured in brain homogenate using a calorimetric kit;  ± SEM. CS activity was measured in isolated mitochondria;  ± SEM.

Correlated values	CI activity [(pmol/sIU CS)]	CIV activity [(pmol/sIU CS)]	GPx-1 activity (mU/mL)	CS activity (IU/mg protein)
Young vs. aged	1545 ± 101 vs. 1625 ± 80	5487 ± 157 vs. 5673 ± 191	1139 ± 50 vs. 1032 ± 48	927 ± 108 vs. 898 ± 104
Aged vs. aged + POS	1625 ± 80 vs. 1587 ± 108	5673 ± 191 vs. 5806 ± 145	1032 ± 48 vs. 1116 ± 60	898 ± 104 vs. 843 ± 118