Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Figure 5

Light and electron microphotographs show the pathological changes of the striatum tissue after exposure to MnCl₂ or cotreatment with AAH or SSZ. The magnification of the sections stained with HE was ×40. Electron microphotograph magnification was ×4000. White arrows represent the nuclear membrane; n representative nuclei; white arrowheads represent mitochondria; black arrows represent endoplasmic reticulum.