Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Table 2

Effects of Mn exposure and AAH pretreatment on ROS and GSH levels in neurons.

Group	ROS (μmol/g pro)	GSH (μmol/g pro)
Control	179.93 ± 3.61	26.85 ± 7.26
100 μM MnCl2	191.79 ± 13.27	20.71 ± 4.11
200 μM MnCl2	254.62 ± 6.85	17.72 ± 4.33
400 μM MnCl2	324.48 ± 6.74	15.31 ± 3.08
250 μM AAH + 400 μM MnCl2	390.9 ± 12.38^##	9.82 ± 1.64^#
1 mM NAC + 400 μM MnCl2	205.94 ± 6.09^##	25.35 ± 5.88^#

Data are mean ± SD; each. , denote statistical significance compared with the control group; , denote statistical significance compared with the MnCl₂ alone group.