Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Table 4

Effects of Mn exposure and AAH or SSZ pretreatment on ROS and GSH levels in the striatum.

Group	ROS (μmol/g pro)	GSH (μmol/g pro)
Control	181.28 ± 7.21	31.25 ± 3.97
12.5 mg/kg MnCl2	335.34 ± 19.47	25.88 ± 6.15
25 mg/kg MnCl2	354.63 ± 8.71	19.07 ± 6.63
50 mg/kg MnCl2	390.18 ± 10.51	13.88 ± 3.39
500 mg/kg AAH + 50 mg/kg MnCl2	415.98 ± 12.44^#	5.83 ± 1.19^#
75 mg/kg SSZ + 50 mg/kg MnCl2	410.27 ± 9.38^#	5.92 ± 1.5^#
100 mg/kg NAC + 50 mg/kg MnCl2	344.73 ± 8.91^##	19.84 ± 4.69^#

Data are mean ± SD; each. denote statistical significance compared with the control group; , denote statistical significance compared with the MnCl₂ alone group.