Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOS/NO-Regulated Oxidative Stress
Aucubin improves survival rates and postinfarction cardiac function. (a) Kaplan-Meier survival analysis of mice in the vehicle-MI and aucubin-MI groups in the first 2 weeks after MI. (b) and (c) Triphenyltetrazolium chloride (TTC, 1%, Sigma, USA) staining of mouse hearts in the vehicle-MI and aucubin-MI groups 2 weeks after MI ((b) representative image and (c) quantitation result). versus vehicle-MI. (d, e) Echocardiographic ((d) LVEF, LEFS) and hemodynamic ((e) heart rate, ESP, EDP, dP/dtmax, and dP/dtmin) results for mice in the four groups at 2 weeks post-MI (). versus vehicle-sham and versus vehicle-MI.