The Function of Thioredoxin-Binding Protein-2 (TBP-2) in Different Diseases

Figure 6

TBP-2 regulates autophagy and apoptosis of HLECs under oxidative stress. Under oxidative stress reduced by ROS, overexpressed TBP-2 can disrupt Trx-ASK1 binding complexes to suppress Trx bioavailability, and in the meantime, raise Bax/Bcl-2 ratio and caspase3/7 activity to activate the ASK1 death pathway to apoptosis. On the other hand, TBP-2 inhibits Akt/Bcl-xL signaling by mTOR independence to facilitate the initial stage of autophagy.