Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells

Figure 7

Schematic diagram of the effects of taurine in ARPE-19 cells. The protective effect of taurine is regulated by the reduction of intracellular ROS from NOXs, leading, in turn, to sequential suppression of calpain induction, ER stress, autophagy, and apoptosis. NADPH oxidases (NOXs) are transmembrane proteins that are localized either in intracellular granules and vesicles or on the cell surface membranes.