Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine

Figure 4

Mouse diaphragm HIF-1α protein content following 8 hours of exposure to normoxia (control), hypoxia, or hypoxia + NAC. Diaphragm HIF-1α protein content (mean ± SEM) expressed as signal/μg of total protein (corrected for background signal) following exposure to either normoxia (control; FiO₂ = 0.21, ), hypoxia (FiO₂ = 0.10, ), or hypoxia + NAC (200 mg/kg i.p. at FiO₂ = 0.10); , , and ; unpaired t tests.