Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine

Figure 8

Mouse diaphragm muscle atrophy and autophagy gene expression following exposure to normoxia (control) or 1, 4, or 8 hours of hypoxia. Fold changes in mRNA expression (relative to the control (normoxia) group) for (a) FoxO-1; (b) FoxO-3; (c) Atrogin-1; (d) MuRF-1; (e) LC3B; (f) BNIP3; and (g) GABARAPL3; mean ± SEM,  = 7–8 per group. versus control, one-way ANOVA and Tukey’s post hoc test following 8 hours of exposure to normoxia and 1, 4, and 8 hours of exposure to hypoxia.

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