Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps

Figure 2

Danshen antagonizes neutrophil functions in tumor-bearing mice. (a) Representative microscopic images of two independent paraffin-embedded lungs from samples from two tumor-bearing mice under 100-fold magnification. Fluorescence staining of sections with NE (green) combined with DAPI (blue). Scale bar indicates 200 μm. The plasma levels of NE (b) and fibrinogen (c) were determined by ELISA assay. Data were expressed as mean ± SD. Statistical comparison between control and treated groups was carried out using Student’s -test ( between control and paclitaxel and between control and DSI). The cell-free DNA (d) was determined based on the fluorescence method ( between control and DSI).

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