Growth Inhibition of a Novel Iron Chelator, DpdtC, against Hepatoma Carcinoma Cell Lines Partly Attributed to Ferritinophagy-Mediated Lysosomal ROS Generation

Figure 6

DpdtC induced ferritin autophagy (ferritinophagy). The nuclei stained by DAPI in blue, ferritin labeled in red, and LC3 labeled in green. (a–d) Control group; (a) nuclei in blue; (b) ferritin in red; (c) LC3 in green; (d) merging of ferritin with LC3. (e–h) DpdtC treated group: (e) nuclei in blue; (f) ferritin in red; (g) LC3 in green; (h) merging of ferritin with LC3. (i–l) DpdtC combined with 3-MA group: (i) nuclei in blue; (j) ferritin in red; (k) LC3 in green; (l) merging of ferritin with LC3, scale bar: 50 μm.

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