From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs

Table 1

Common gene targets of microRNAs with possible role in oxidative stress. Common targets of 13 oxidative stress-modulated miRNAs: hsa-let7f (91 elements), hsa-miR-9 (936 elements), hsa-miR-16 (294 elements), hsa-miR-21 (105 elements), hsa-miR-22 (330 elements), hsa-miR-29b (158 elements), hsa-miR-99a (24 elements), hsa-miR-125b (412 elements), hsa-miR-128 (785 elements), hsa-miR-143 (263 elements), hsa-miR-144 (647 elements), hsa-miR-155 (281 elements), and hsa-miR-200c (34 elements). Listed are 13 gene targets found to be common to 5, 6, or 7 of the 13 oxidative stress-modulated miRNAs. The database used for this analysis was TargetScan [13]. The miRNA-target genes marked in italics have already been validated and described to be involved in oxidative stress responses.

Target gene	Annotation	Common miRNAs
ZNF618	Zinc finger protein 618	hsa-miR-9; hsa-miR-22; hsa-miR-125b; hsa-miR-128; hsa-miR-143; hsa-miR-144; hsa-miR-155
SH3PXD2A	SH3 and PX domains 2A	hsa-miR-9; hsa-miR-22; hsa-miR-29b; hsa-miR-143; hsa-miR-144; hsa-miR-155
TNRC6B	Trinucleotide repeat containing 6B	hsa-miR-9; hsa-miR-16; hsa-miR-29b; hsa-miR-128; hsa-miR-144; hsa-miR-22
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	let-7f; hsa-miR-9; hsa-miR-22; hsa-miR-143; hsa-miR-155
CPEB3	Cytoplasmic polyadenylation element binding protein 3	hsa-miR-9; hsa-miR-16; hsa-miR-21; hsa-miR-128; hsa-miR-144
PPARA	Peroxisome proliferator-activated receptor alpha	hsa-miR-9; hsa-miR-22; hsa-miR-21; hsa-miR-128; hsa-miR-144
CLCN5	Chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease)	hsa-miR-9; hsa-miR-16; hsa-miR-22; hsa-miR-128; hsa-miR-155
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	hsa-miR-9; hsa-miR-16; hsa-miR-125b; hsa-miR-128; hsa-miR-144
LIFR	Leukemia inhibitory factor receptor alpha	hsa-miR-9; hsa-miR-143; hsa-miR-21; hsa-miR-128; hsa-miR-144
KCNA1	Potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	hsa-miR-9; hsa-miR-155; hsa-miR-21; hsa-miR-128; hsa-miR-144
USP31	Ubiquitin-specific peptidase 31	hsa-miR-9; hsa-miR-16; hsa-miR-155; hsa-miR-200c; hsa-miR-144
tcag7.1228	Hypothetical protein FLJ25778	hsa-miR-9; hsa-miR-16; hsa-miR-21; hsa-miR-128; hsa-miR-144
NFIB	Nuclear factor I/B	hsa-miR-9; hsa-miR-22; hsa-miR-21; hsa-miR-128; hsa-miR-29b

Note: see Supplementary Table 1 for this table in Excel format, and see Supplementary Table 2 for a full list of gene targets found to be common to ≥2 of the 13 oxidative stress-modulated miRNAs (i.e., all possible combinations).