Reduced Susceptibility to Sugar-Induced Metabolic Derangements and Impairments of Myocardial Redox Signaling in Mice Chronically Fed with D-Tagatose when Compared to Fructose
Effects of liquid sugars feeding on myocardial activation of the NF-κB pathway. Representative Western blotting and relative densitometric analysis of the activation of the NF-κB pathway measured as phosphorylation of IKKα/β at Ser176/180 (a), phosphorylation of IκBα at Ser32/36 (b), and nuclear translocation of p65 subunit of NF-κB (c) in the heart of mice fed for 24 weeks with a control diet or with a diet containing liquid supplementation of fructose/D-tagatose. Protein expression was measured as relative optical density (OD), corrected for the corresponding tubulin or histone H3 contents and normalized using the related CD band. Values are represented as means ± S.E.M. of 6 animals per group. denotes vs. CD. ## denotes vs. L-Tg diet.
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