Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development

Figure 2

Differential regulation of STRAP functions by phosphorylation. (a) STRAP phosphorylation at Thr¹⁷⁵ and Ser¹⁷⁹ by ASK1 for STRAP-mediated inhibition of ASK1-induced cell death [16]. (b) STRAP Ser¹⁸⁸ phosphorylation by MPK38 leads to cell death by modulating both STRAP- and MPK38-mediated ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways [14]. P: phosphorylated; ASK1: apoptosis signal-regulating kinase 1; PDK1: 3-phosphoinositide-dependent protein kinase-1; MPK38: murine protein serine/threonine kinase 38.

(a) Antiapoptotic function of STRAP

(b) Proapoptotic function of STRAP