Exendin-4 and Liraglutide Attenuate Glucose Toxicity-Induced Cardiac Injury through mTOR/ULK1-Dependent Autophagy

<div>Effect of exendin-4 (Exe) and liraglutide (LIRA) on glucose toxicity-induced elevation of apoptotic proteins: (a) representative gel bands of cleaved caspase-3, Bax, Bcl-2, and GAPDH (loading control) using specific antibodies; (b) quantitative analysis of cleaved caspase-3; (c) quantitative analysis of the Bax-to-Bcl-2 ratio. <span class="nowrap"><svg height="9.11633pt" id="M21" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.7664 68.2966 9.11633" width="68.2966pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z" id="g121-75"></path></g><g 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Exendin-4 and Liraglutide Attenuate Glucose Toxicity-Induced Cardiac Injury through mTOR/ULK1-Dependent Autophagy 