The Role of Nrf2 Signaling in PPARβ/δ-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress

Figure 4

Role of the PPARβ/δ activation on the Nrf2/ARE pathway. mRNA expression levels of (a) Nrf2, (b) NOQ-1, and (c) HO-1 in control siRNA and siRNA PPARβ/δ cells incubated in low- (LG) or high-glucose (HG) medium for 24 h, in the presence or absence of GW0742 (GW, 10⁻⁶ M). mRNA data presented as a ratio of arbitrary units of mRNA (2^−ΔΔCt). All data are mean ± SEM (), and experiments were repeated at least three times independently. versus LG. and versus HG.

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