Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice
Cholesterol content and the Caveolin-1 protein level in skeletal muscle crude mitochondria and homogenates in the ALS and WT mice. Cholesterol content was assessed in skeletal muscle crude mitochondrial fraction (a) and homogenates (b). The Caveolin-1 protein level was measured in skeletal muscle crude mitochondrial fraction (c) and homogenates (d). There were significant differences between the groups: versus ALS 0 or WT 0, respectively, versus ALS TER, versus ALS TER (unpaired Student’s t-test); and between the indicated ALS and corresponding WT groups. The data are presented as the means ± SEM ( in each group).