Transplantation of Bone Marrow Mesenchymal Stem Cells Prevents Radiation-Induced Artery Injury by Suppressing Oxidative Stress and Inflammation

Figure 2

hBMSCs alleviated radiation-induced aortic pathological changes. Male C57BL/6 mice were irradiated by 6MV X-ray of 18Gy once with their lungs were shielded to establish the RIAI model. hBMSCs were injected by tail vein in a dose of 10³ or 10⁴ cells/g of body weight within 24 h after radiation. Therefore, the mice were evenly divided into four groups: the control group (control), the radiation group (IR), the radiation with low or high dose of the hBMSC group (IR + LD hBMSCs and IR + HD hBMSCs). At 3, 7, 14, 28, and 84 days after radiation, the aortas were isolated for histological studies. The pathological changes of aortas were examined by HE staining (a) and the accumulation of collagen was detected by Sirius red staining (b), followed by semiquantitative analysis. Data were presented as means ± SD (). versus control group; versus IR group; versus IR + LD hBMSC group. Scale bar, 50 μm.

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(b)