Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 5969486, 10 pages
https://doi.org/10.1155/2018/5969486
Research Article

The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes

1Department of Physiology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Despota Stefana 142, 11000 Belgrade, Serbia
2Department of Biochemistry, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Despota Stefana 142, 11000 Belgrade, Serbia
3OMI Institute, Trnovska 8, SI-1000 Ljubljana, Slovenia
4Institute of Pathophysiology, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia

Correspondence should be addressed to Duško Blagojević; sr.ca.gb.ssibi@ejogalbd

Received 17 November 2017; Accepted 28 December 2017; Published 11 February 2018

Academic Editor: Angel Catalá

Copyright © 2018 Zorana Oreščanin-Dušić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. R. Alper, H. S. Lotsof, G. M. Frenken, D. J. Luciano, and J. Bastiaans, “Treatment of acute opioid withdrawal with ibogaine,” The American Journal on Addictions, vol. 8, no. 3, pp. 234–242, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. J. R. Donnelly, “The need for ibogaine in drug and alcohol addiction treatment,” The Journal of Legal Medicine, vol. 32, no. 1, pp. 93–114, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Maciulaitis, V. Kontrimaviciute, F. M. Bressolle, and V. Briedis, “Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review,” Human & Experimental Toxicology, vol. 27, no. 3, pp. 181–194, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Glue, G. Cape, D. Tunnicliff et al., “Ascending single-dose, double-blind, placebo-controlled safety study of noribogaine in opioid-dependent patients,” Clinical Pharmacology in Drug Development, vol. 5, no. 6, pp. 460–468, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. K. R. Alper, “Ibogaine: a review,” The Alkaloids: Chemistry and Biology, vol. 56, pp. 1–38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. S. D. Glick, I. M. Maisonneuve, B. A. Kitchen, and M. W. Fleck, “Antagonism of α3β4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration,” European Journal of Pharmacology, vol. 438, no. 1-2, pp. 99–105, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. M. B. Leal, K. Michelin, D. O. Souza, and E. Elisabetsky, “Ibogaine attenuation of morphine withdrawal in mice: role of glutamate N-methyl-D-aspartate receptors,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 27, no. 5, pp. 781–785, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Paskulin, P. Jamnik, N. Obermajer, M. Slavic, and B. Strukelj, “Induction of energy metabolism related enzymes in yeast Saccharomyces cerevisiae exposed to ibogaine is adaptation to acute decrease in ATP energy pool,” European Journal of Pharmacology, vol. 627, no. 1–3, pp. 131–135, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Paskulin, P. Jamnik, T. Danevcic et al., “Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga,” Journal of Ethnopharmacology, vol. 143, no. 1, pp. 319–324, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Nikolić-Kokić, Z. Oreščanin-Dušić, I. Spasojević et al., “Ex vivo effects of ibogaine on the activity of antioxidative enzymes in human erythrocytes,” Journal of Ethnopharmacology, vol. 164, pp. 64–70, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Paskulin, P. Jamnik, M. Zivin, P. Raspor, and B. Strukelj, “Ibogaine affects brain energy metabolism,” European Journal of Pharmacology, vol. 552, no. 1–3, pp. 11–14, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. M. G. Zizzo, F. Mulè, and R. Serio, “Activation of P2Y receptors by ATP and by its analogue, ADPβS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal colon,” European Journal of Pharmacology, vol. 595, no. 1–3, pp. 84–89, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. H. A. Zafrah and M. F. Alotaibi, “The effect of extracellular ATP on rat uterine contraction from different gestational stages and its possible mechanisms of action,” Journal of Basic and Clinical Physiology and Pharmacology, vol. 28, no. 3, pp. 209–217, 2017. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Y. Warren, B. Matharoo-Ball, R. W. Shaw, and R. N. Khan, “Hydrogen peroxide and superoxide anion modulate pregnant human myometrial contractility,” Reproduction, vol. 130, no. 4, pp. 539–544, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Appiah, S. Milovanović, R. Radojičić et al., “Hydrogen peroxide affects contractile activity and anti-oxidant enzymes in rat uterus,” British Journal of Pharmacology, vol. 158, no. 8, pp. 1932–1941, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Appiah, A. Nikolic-Kokic, Z. Orescanin-Dusic et al., “Reversible oxidation of myometrial voltage-gated potassium channels with hydrogen peroxide,” Oxidative Medicine and Cellular Longevity, vol. 2012, Article ID 105820, 7 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Nikolić-Kokić, Z. Oreščanin-Dušić, I. Spasojević et al., “The effects of wild-type and mutant SOD1 on smooth muscle contraction,” Archives of Biological Sciences, vol. 67, no. 1, pp. 187–192, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. F. K. Marcondes, F. I. Bianchi, and A. P. Tanno, “Determination of the estrous cycle phases of rats: some helpful considerations,” Brazilian Journal of Biology, vol. 62, no. 4a, pp. 609–614, 2002. View at Publisher · View at Google Scholar
  19. H. P. Misra and I. Fridovich, “The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase,” Journal of Biological Chemistry, vol. 247, no. 10, pp. 3170–3175, 1972. View at Google Scholar
  20. E. Beutler, Red Cell Metabolism – A Manual of Biochemical Methods, Grune and Stratton, New York, NY, USA, third edition, 1982.
  21. D. E. Paglia and W. N. Valentine, “Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase,” The Journal of Laboratory and Clinical Medicine, vol. 70, pp. 158–169, 1967. View at Google Scholar
  22. D. Glatzle, J. P. Vuilleumie, F. Weber, and K. Decker, “Glutathione reductase test with whole blood, a convenient procedure for the assessment of the riboflavin status in humans,” Experientia, vol. 30, no. 6, pp. 665–667, 1974. View at Publisher · View at Google Scholar · View at Scopus
  23. O. H. Lowry, N. L. Rosebrough, A. L. Farr, and R. I. Randall, “Protein measurement with Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar
  24. E. D. Hinkle, W. Wiersma, and G. S. Jurs, Applied Statistics for Behavioral Sciences, Houghton Mifflin Company, Boston, MA, USA, fifth edition, 2002.
  25. J. G. Fitz, “Regulation of cellular ATP release,” Transactions of the American Clinical and Climatological Association, vol. 118, pp. 199–208, 2007. View at Google Scholar
  26. G. Dahl, “ATP release through pannexon channels,” Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 370, no. 1672, article 20140191, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. K. E. Hodgson and I. Fridovich, “The interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide: inactivation of the enzyme,” Biochemistry, vol. 14, no. 24, pp. 5294–5299, 1975. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Slavic, I. Appiah, A. Nikolic-Kokic et al., “The anti-oxidative defence system in the isolated rat uterus during spontaneous rhythmic activity,” Acta Physiologica Hungarica, vol. 93, no. 4, pp. 335–339, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Porta, A. Vahedi-Faridi, and G. Borgstahl, “Structural analysis of peroxide-soaked MnSOD crystals reveals side-on binding of peroxide to active-site manganese,” Journal of Molecular Biology, vol. 399, no. 3, pp. 377–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. D. N. Silverman and H. S. Nick, “Catalytic pathway of manganese superoxide dismutase by direct observation of superoxide,” Methods in Enzymology, vol. 349, pp. 61–74, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. S. G. Rhee, K. S. Yang, S. W. Kang, H. A. Woo, and T. S. Chang, “Controlled elimination of intracellular H2O2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification,” Antioxidants & Redox Signaling, vol. 7, no. 5-6, pp. 619–626, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Cao, Y. Leng, and D. Kufe, “Catalase activity is regulated by c-Abl and Arg in the oxidative stress response,” Journal of Biological Chemistry, vol. 278, no. 32, pp. 29667–29675, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Yano and N. Yano, “Regulation of catalase enzyme activity by cell signaling molecules,” Molecular and Cellular Biochemistry, vol. 240, no. 1-2, pp. 119–130, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. I. Bogeski, M. Bozem, L. Sternfeld, H. W. Hofer, and I. Schulz, “Inhibition of protein tyrosine phosphatase 1B by reactive oxygen species leads to maintenance of Ca2+ influx following store depletion in HEK 293 cells,” Cell Calcium, vol. 40, no. 1, pp. 1–10, 2006. View at Publisher · View at Google Scholar · View at Scopus