Combined Therapy with Extracorporeal Shock Wave and Adipose-Derived Mesenchymal Stem Cells Remarkably Improved Acute Ischemia-Reperfusion Injury of Quadriceps Muscle

Figure 9

Protein expressions of inflammatory biomarkers in the quadriceps by day 7 after the IR procedure. (a) Protein expression of intercellular adhesion molecule- (ICAM-) 1. versus other groups with different symbols (†, ‡, §, and ¶), . (b) Protein expression of matrix metalloproteinase- (MMP-) 9. versus other groups with different symbols (†, ‡, §, and ¶), . (c) Protein expression of tumor necrosis factor- (TNF-) α. versus other groups with different symbols (†, ‡, §, and ¶), . (d) Protein expression of nuclear factor- (NF-) κB. versus other groups with different symbols (†, ‡, §, and ¶), . (e) Protein expression of RANTES. versus other groups with different symbols (†, ‡, §, and ¶), . (f) Protein expression of toll-like receptor- (TLR-) 2. versus other groups with different symbols (†, ‡, §, and ¶), . (g) Protein expression of TLR-4. versus other groups with different symbols (†, ‡, §, and ¶), . (h) Protein expression of interleukin- (IL-) 1β. versus other groups with different symbols (†, ‡, §, and ¶), . All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test ( for each group). Symbols (, †, ‡, §, and ¶) indicate significance at the 0.05 level. SC = sham control; IR = ischemia-reperfusion; ECSW = extracorporeal shock wave; ADMSC = adipose-derived mesenchymal stem cell.

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