Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases

Figure 3

Diagram depicting network of coordinated interaction between miRNA and mTOR pathway in the regulation of cardiovascular diseases. Fibroblast growth factor receptors (FGFR); insulin-like growth factor 1 (IGF-1) sphingosine kinase 2 (Spk2); regulation of proline-rich AKT substrate 40 kDa (PRAS40); phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K); phosphoinositide-dependent kinase l (PDK1); calcium-binding protein 39 (Cab39); poly (ADP-ribose) polymerase (PARP); SRY-related HMG-box 8 (SOX8); programmed cell death protein 4 (PDCD4); Ras homolog gene family, member B (RhoB); phosphatase and tensin homolog (PTEN); vascular endothelial growth factor (VEGF); hypoxia-inducible factors (HIF); tuberous sclerosis protein (TSC1/2); ras homolog enriched in brain (Rheb); ribosomal protein S6 kinase beta-1 (S6K1); proviral integration site for Moloney murine leukemia virus-1 (Pim-1).