Review Article

Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress

Table 1

Nanoparticles and their biological effects.

ReferencesNanoparticle studiedFunctionCell type

Manickam et al. [112]Iron oxide nanoparticlesOxidant by Nox 4 overexpressionMyocardium from mice
Petty [117]WO3-Pt nanoparticlesOxidant. NADPH oxidase biomimeticTumor cells
Sun et al. [113]Silver nanoparticlesOxidant by increasing Nox 4 expressionHuman umbilical vein endothelial cells
Ramirez-Lee et al. [131]Silver nanoparticlesIncrease of hypertension due to a decrease in NO levelsMyocardium from rats
T. Yu et al. [142]PLGA nanoparticlesCarrier. Treatment for hypertensionHypertensive rats
Le et al. [132]PLGA nanoparticlesROS scavenger at vascular level and endothelial protectorHuman umbilical vascular endothelial cells
Reddy and Labhasetwar [63]PLGA nanoparticlesSOD carrierRat focal cerebral ischemia/reperfusion injury
Hennig et al. [141]PEGylated quantum dotsCarrier of angiotensin IIAT1R-expressing cells
C. Guo et al. [158]Silica nanoparticlesEndothelial injury induced by mitochondrial dysfunctionHuman endothelial cells
Farooq et al. [157]Silica nanoparticlesEndothelial dysfunction induced by oxidative stressAorta from rat
D. Lee et al. [71]PVAXAntioxidant, anti-inflammatory, and antiapoptotic activityHind-limb and liver from an ischemia/reperfusion model in mice
Marrache and Dhar [80]PLGA-b-PEG-TPP nanoparticlesNanocarriersMitochondria-acting therapeutics
Marushima et al. [73]RNPNeuroprotective agent due to its ability to scavenge free radicalsMiddle cerebral artery from rats with cerebral ischemia/reperfusion injury
Chonpathompikunlert et al. [74]Redox-polymer nanotherapeuticsTreatment of the neurodegenerative diseasesBrain from SAMP8 mice
Ciofani et al. [60]NanoceriaSOD and catalase mimeticPC12 neuronal-like cells
Estevez et al. [69]NanoceriaReduction of oxidative and nitrosative damage after strokeMouse hippocampal brain slice model of ischemia
Hirst et al. [67]NanoceriaAnti-inflammatory and NO scavengerMurine macrophages
Niu et al. [152]NanoceriaAntioxidantCultured rat H9c2 cardiomyocytes
Niu et al. [161]NanoceriaAntioxidant and anti-inflammatoryMurine myocardium
Gojova et al. [164]NanoceriaInflammatory effectHuman aortic endothelial cells
Wingard et al. [162]NanoceriaVascular dysfunctionAorta from mice
Minarchick et al. [159]NanoceriaVascular antioxidantArterioles from hypertensive rats
Minarchick et al. [163]NanoceriaProoxidant. Microvascular dysfunctionArteriola from rats
Kennedy et al. [165]Iron oxide, yttrium oxide, cerium oxide, zinc oxideProinflammatoryHuman vascular endothelial cell line
Park et al. [187]Nanoparticles based on polyoxalateAntioxidant and anti-inflammatoryDoxorubicin-treated mice heart
Seshadri et al. [189]Polyketal particlesSOD carrierRat myocardium

WO3-Pt: platinum tungsten oxide; PLGA: copolymer poly (lactic-co-glycolic acid); SOD: superoxide dismutase; PEG: polyethylene glycol; PVAX: copolyoxalate containing vanillyl alcohol (VA); RNP: radical-containing-nanoparticles.