Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet-Induced Accumulation of Lipid in the Liver of ApoE^−/− Mice

Table 5

Fatty acid composition (%) of the serum of mice during the experimental period.

Serum fatty acid	ND ()	HFD ()	DHA/EPA = 2 : 1 ()	DHA/EPA = 1 : 1 ()	DHA/EPA = 1 : 2 ()
C16:0	22.881 ± 0.863	23.293 ± 0.271	22.759 ± 0.762	22.068 ± 0.763	20.838 ± 1.006
C16:1	1.069 ± 0.117	1.473 ± 0.145^a	0.773 ± 0.287^b	0.65 ± 0.168^b	0.666 ± 0.174^b
C18:0	8.151 ± 0.345	11.729 ± 0.440^a	9.163 ± 0.510^b	9.071 ± 0.336^b	8.871 ± 0.576^b
C18:1	16.136 ± 0.603	26.315 ± 0.857^a	17.374 ± 1.279^b	16.886 ± 1.21^b	16.174 ± 1.967^b
C18:2	30.819 ± 1.416	20.912 ± 0.605^a	30.538 ± 1.028^b	30.515 ± 1.039^b	28.062 ± 1.046^a,b
C18:3	0.00 ± 0.00	0.00 ± 0.00	0.04 ± 0.08	0.00 ± 0.00	0.00 ± 0.00
C19:0	0.836 ± 0.040	0.538 ± 0.137	0.500 ± 0.168	0.266 ± 0.1646^a	0.260 ± 0.162^a
C20:0	0.112 ± 0.112	0.082 ± 0.0.082	0.133 ± 0.133	0.098 ± 0.098	0.00 ± 0.00
C20:1	0.106 ± 0.106	0.228 ± 0.140	0.748 ± 0.329	0.416 ± 0.289	0.424 ± 0.309
C20:4	4.265 ± 0.272	7.177 ± 0.458^a	3.67 ± 0.132^b	3.946 ± 0.126^b	4.242 ± 0.184^b
C22:0	2.01 ± 0.059	0.660 ± 0.093	4.018 ± 1.264^a,b	4.383 ± 0.518^a,b	5.472 ± 0.775^a,b
C20:5	0.752 ± 0.313	0.00 ± 0.00^a	0.275 ± 0.166	0.102 ± 0.102^a	0.130 ± 0.130^a
C22:6	7.028 ± 0.305	3.555 ± 0.221^a	8.389 ± 0.371^a,b	8.347 ± 0.265^a,b	7.358 ± 0.429^b,c,d
∑SFAs	33.987 ± 1.153	36.305 ± 0.321	36.575 ± 0.697	35.885 ± 0.986	35.439 ± 0.969
∑MUFAs	17.314 ± 0.598	28.018 ± 0.805^a	18.895 ± 1.131^b	17.952 ± 1.090^b	17.266 ± 1.845^b
∑PUFAs	42.866 ± 1.969	31.648 ± 0.510^a	42.878 ± 1.189^b	42.908 ± 0.721^b	39.794 ± 1.124^b
∑n-6	35.086 ± 1.659	28.092 ± 0.339^a	34.213 ± 1.021^b	34.460 ± 0.927^b	32.306 ± 1.134^b
∑n-3	7.780 ± 0.393	3.556 ± 0.222^a	8.665 ± 0.493^b	8.448 ± 0.253^b	7.488 ± 0.388^b,c
n-6/n-3	4.522 ± 0.162	8.016 ± 0.469^a	3.983 ± 0.241^b	4.105 ± 0.224^b	4.372 ± 0.320^b

Data are given as the mean ± SEM. ^a versus the ND group; ^b versus the HFD group; ^c versus the DHA/EPA = 2 : 1 group; ^d versus the DHA/EPA = 1 : 1 group.