Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates Diet-Induced Accumulation of Lipid in the Liver of ApoE^−/− Mice

Table 6

Fatty acid composition (%) of the liver of mice during the experimental period.

Hepatic fatty acid	ND ()	HFD ()	DHA/EPA = 2 : 1 ()	DHA/EPA = 1 : 1 ()	DHA/EPA = 1 : 2 ()
C16:0	26. 228 ± 0.799	20.211 ± 0.217^a	22.596 ± 0.689^a	21.261 ± 1.272^a	20.590 ± 0.116^a
C16:1	0.00 ± 0.000	1.640 ± 0.247^a	0.48 ± 0.045^a,b	0.489 ± 0.104^a,b	0.577 ± 0.044^a,b
C18:0	10.905 ± 0.797	8.772 ± 0.399	11.234 ± 0.922	10.545 ± 1.303	7.260 ± 0.297^a,c,d
C18:1	13.451 ± 0.814	30.939 ± 0.911^a	15.386 ± 1.691^b	17.971 ± 3.113^b	20.368 ± 1.028^a,b
C18:2	25.962 ± 0.722	19.456 ± 0.555^a	24.647 ± 0.708^b	23.941 ± 0.966^b	26.889 ± 0.404^b,d
C18:3	0.452 ± 0.029	0.546 ± 0.059	0.099 ± 0.011^a,b	0.231 ± 0.049^a,b,c	0.133 ± 0.009^a,b
C19:0	0.397 ± 0.049	0.293 ± 0.093	0.284 ± 0.057	0.188 ± 0.069^a	0.334 ± 0.024
C20:0	0.358 ± 0.019	0.617 ± 0.208	0.333 ± 0.026^b	0.431 ± 0.043	0.391 ± 0.032
C20:1	0.710 ± 0.074	0.689 ± 0.021	0.879 ± 0.099	0.894 ± 0.118	0.567 ± 0.041^c,d
C20:4	6.371 ± 0.435	7.525 ± 0.381	5.332 ± 0.388^b	5.489 ± 0.738^b	4.932 ± 0.335^b
C22:0	0.880 ± 0.041	0.156 ± 0.012^a	1.506 ± 0.046^a,b	1.98 ± 0.081^a,b,c	1.800 ± 0.138^a,b,c
C20:5	0.804 ± 0.064	0.451 ± 0.076^a	1.086 ± 0.056^a,b	1.315 ± 0.074^a,b,c	1.527 ± 0.096^a,b,c
C22:6	10.425 ± 0.223	4.289 ± 0.281^a	12.895 ± 0.530^a,b	11.761 ± 1.000^b	10.301 ± 0.483^b,c
∑SFAs	38.770 ± 1.345	30.053 ± 0.432^a	35.948 ± 1.489^b	34.403 ± 2.263^a	30.377 ± 0.126^a,c
∑MUFAs	14.166 ± 0.782	33.269 ± 1.066^a	16.746 ± 1.644^b	19.358 ± 3.044^a,b	21.517 ± 1.032^a,b
∑PUFAs	44.016 ± 0.467	32.268 ± 0.757^a	44.064 ± 0.578^b	42.738 ± 0.826^b	43.787 ± 0.492^b
∑n-6	32.334 ± 0.643	26.983 ± 0.484^a	29.982 ± 0.383^a,b	29.43 ± 0.249^a,b	31.823 ± 0.143^b,c,d
∑n-3	11.682 ± 0.255	5.285 ± 0.293^a	14.082 ± 0.519^a,b	13.308 ± 1.069^b	11.963 ± 0.387^b,c
n-6/n-3	2.778 ± 0.116	5.138 ± 0.202^a	2.141 ± 0.081^a,b	2.266 ± 0.228^a,b	2.665 ± 0.082^b,c

Data are given as mean ± SEM. ^a versus the ND group; ^b versus the HFD group; ^c versus the DHA/EPA = 2 : 1 group; ^d versus the DHA/EPA = 1 : 1 group.