Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology

Figure 5

Crystallographic structure of human cystathionine γ-lyase (CSE). (a) Cartoon representation of human CSE homotetramer (PDB ID: 3COG; 2.0 Å resolution) cocrystallized with the inhibitor propargylglycine (PPG). Each chain is represented in a different colour. Green sticks, active site PLP moiety where H₂S production occurs. (b) Zoom-in into the catalytic PLP site. The PLP moiety (green sticks) is covalently attached to CSE through Lys₂₁₂ (human CSE numbering); PPG is represented in blue sticks. Figure generated with PyMol 1.8.2.0 [238].