ZP2495 Protects against Myocardial Ischemia/Reperfusion Injury in Diabetic Mice through Improvement of Cardiac Metabolism and Mitochondrial Function: The Possible Involvement of AMPK-FoxO3a Signal Pathway

Figure 4

ZP2495 regulated Akt, FoxO3a, and apoptosis-related protein expression. (a) Representative blots of p-Akt, Akt, p-Bad, Bad, p-FoxO3a, FoxO3a, BimEL, MnSOD, catalase, Bax, and Bcl-2 in cardiomyocyte of db/db mice subjected to I/R. (b–g) Semiquantitative analysis of the Western blots. Sham: BKS + sham group; db/db: db/db + sham group; I/R: db/db + I/R group; ZP2495: db/db + I/R + ZP2495 group; glucagon: db/db + I/R + glucagon group; and ZP131: db/db + I/R + ZP131 group. Presented values are mean ± SEM. versus the sham group; versus the db/db group; ^$ versus the db/db + I/R group; and ^£ versus the db/db + I/R + ZP2495 group.

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