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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 6798238, 8 pages
Research Article

Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor

1Post Graduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil
2Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José dos Campos, SP, Brazil
3Experimental Cardiorespiratory Physiology Laboratory, Master’s Degree and PhD Program in Rehabilitation Sciences, University Nove de Julho (UNINOVE), Sao Paulo, SP, Brazil
4Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, Department of Surgery, University of California San Diego (UCSD) Health Sciences, San Diego, CA, USA
5Institute of Science and Technology, Federal University of São Paulo (UNIFESP), Sao José dos Campos, SP, Brazil
6Post-graduation Program in Bioengineering, Universidade Brasil, São Paulo, SP, Brazil
7Post-graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil

Correspondence should be addressed to Ana Paula Ligeiro-de-Oliveira; moc.liamg@oriegilpa

Received 28 June 2017; Accepted 9 December 2017; Published 4 March 2018

Academic Editor: Saeid Golbidi

Copyright © 2018 Gabriel da Cunha Moraes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm2) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1β, IL-6, and TNF-α in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.