Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer’s Disease

Figure 2

Differential gene expression analysis in TRIM59 and KLF14. The KLF14 and TRIM59 networks contained 21 differentially expressed genes each and were visualized on the heatmaps (a, b) and volcano plots (c, d). Multidimensional scaling analysis of the networks revealed high level of specificity of individual genes in the two compared datasets of fEOAD and controls, which is highlighted in red and black circles on the graphs (e, f).

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