Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress

Table 2

Effects of TRZ on the sperm concentration, motility, and morphology of male rats.

	C	TRZ-5	TRZ-10	TRZ-20
Sperm concentration (10^6/ml)	4.68 ± 0.30	3.04 ± 0.21	2.84 ± 0.12	2.68 ± 0.21
Sperm motility (%)	86.49 ± 1.23	80.06 ± 0.93	78.85 ± 1.01	76.23 ± 0.83
Abnormal sperm count (%)	18.00 ± 1.12	28.90 ± 1.98	31.20 ± 0.65	37.08 ± 1.10

C: control group; TRZ-5: 5 mg kg⁻¹ trazodone-treated rats for the 28-day group; TRZ-10: 10 mg kg⁻¹ trazodone-treated rats for the 28-day group; TRZ-20: 20 mg kg⁻¹ trazodone-treated rats for the 28-day group. All data were expressed as mean ± standard error. Different from C (). Different from C ().