|
Structural type | No | Name of compounds | Nrf2-inducing activity | Cell or animal models | Ref |
|
Diterpenoid quinones | 1 | Tanshindiol B | 6.80-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
4.85 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
2 | 17-Hydroxycryptotanshinone | 3.97-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
3 | Isotanshinone IIA | 6.45-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
4 | Trijuganone A | 4.31-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
5 | Tanshinone IIB | 5.34-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
4.85 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
6 | Przewaquinone A | 6.01-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
7 | Przewaquinone B | 7.27-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
8 | 1-Ketoisocryptotanshinone | 5.65-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
9 | 15,16-Dihydrotanshinone I | 3.38-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
4.80 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
Induction of ARE luciferase and upregulation of Nrf2 protein level | MDA-MB-231 cells | [40] |
Induction of Nrf2, NQO1, and γ-GCS protein levels | Human dermal fibroblasts. | [41] |
10 | 1,2,15,16-Tetrahydrotanshinone I | 4.37-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
11 | Cryptotanshinone | 3.61-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
5.07 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
Induction of ARE luciferase and upregulation of Nrf2 protein level | MDA-MB-231 cells | [40] |
Induction of ARE-luciferase activity | Hep G2 cells | [26] |
12 | Tanshinone I | 2.60-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
5.90 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
Induction of ARE luciferase and upregulation of Nrf2 protein level | MDA-MB-231 cells | [40] |
Upregulation of Nrf2, HO-1, GCLC, and GCLM | SH-SY5Y cells | [42, 43] |
Induction of ARE-luciferase activity | Hep G2 cells | [26] |
Induction of Nrf2, NQO1, and γ-GCS protein levels | Human dermal fibroblasts | [41] |
13 | RO-090680 | 3.06-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
14 | Methylenetanshinquinone | 2.77-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
15 | 1,2-Didehydromilitirone | 3.79-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
1.04 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
16 | Tanshinone IIA | 2.58-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
5.10 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
Upregulation of Nrf2, HO-1, and NQO-1 protein levels | JB6 cells | [44] |
Induction of ARE luciferase and upregulation of Nrf2 protein level | MDA-MB-231 cells | [40] |
Upregulation of Nrf2, NOQ-1, HO-1, GCLC, and GCLM protein levels | Human aortic smooth muscle cells. | [45] |
Induction of ARE-luciferase activity and upregulation of mRNA levels of GCLC, NQO1, and HO-1 | Hepa G2 cells | [26] |
Induction of Nrf2 and upregulation of mRNA and protein levels of HO-1, NQO1, and GCLC | SH-SY5Y cells | [46] |
17 | Miltirone | 3.32-fold induction of ARE luciferase activity | HEK 293 T cells | [38] |
0.92 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
Enhancement of Nrf2 translocation and upregulation mRNA and protein levels of Nrf2, HO-1, and NQO1 | EA.hy926 cells | [47] |
18 | 17-Hydroxycryptotanshinone | 4.85 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
19 | 1-Oxomiltirone | 0.40 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
20 | 4-Methylenemiltirone | 0.46 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
21 | 1,2-Dihydrotanshinone I | 5.40 μM for 2-fold induction of QR activity | Hepa 1c1c7 cells | [39] |
|
Phenolic acids | 22 | Danshensu | Upregulation of mRNA and protein levels of Nrf2 | Rat heart | [48] |
23 | Rosmarinic acid | Upregulation of Nrf2 and HO-1 protein level | Rat cochlea | [49] |
24 | Salvianolic acid A | Induction of mRNA and protein levels of Nrf2 and HO-1 | RPE cells | [50, 51] |
25 | Salvianolic acid B | Induction of Nrf2 and HO-1 | Rat lung tissue | [52] |
Induction of Nrf2 protein level | Rat primary neurons | [53] |
Induction of Nrf2, HO-1, and GCLC protein levels | Hepa G2 cells | [54] |
|