Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice

Figure 2

Inflammatory infiltrate and pathological remodeling of the cardiac tissue from mice infected with Trypanosoma cruzi and treated with the nonselective purinergic antagonist suramin. Vv Hc (%): volume density of myocardial components. SAL: 0.9% NaCl solution; INF: untreated and infected; SR5, SR10, and SR20: infected and treated with 5, 10, or 20 mg suramin/kg, respectively. † ‡ Statistical difference (): compared to SAL; † SAL, INF, and SR5; ‡ SAL, INF, SR5, and SR10.