Oxidative Medicine and Cellular Longevity / 2018 / Article / Tab 1

Review Article

The Role of Oxidative Stress in the Pathomechanism of Congenital Malformations

Table 1

Summary of the markers investigating in relation to oxidative damage in Down syndrome.

MarkerDS cell/tissueLevel

SOD1ErythrocytesIncreased
B- and T-lymphocytesIncreased
FibroblastsIncreased
Whole bloodIncreased activity

Peroxiredoxin 2Fetal brainDecreased

CATWhole bloodIncreased activity

Protein carbonylsWhole bloodIncreased
Amniotic fluidIncreased

Total Glutathione GSSGAmniotic fluidIncreased
Increased
Trx
Decreased

ROSPrimary human cortical cell culturesIncreased

Lipid peroxidationPrimary human cortical cell culturesIncreased

BACH1 proteinFrontal cortex tissueIncreased

Aβ40 and Aβ42PlasmaIncreased

CRBBrainIncreased

GSHWhole bloodDecreased

HNE-protein adductsAmniotic fluidIncreased

HSP 70
Grp 78
HO-1
Amniotic fluidIncreased

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