The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2-Mediated Oxidative Stress in the db/db Mouse

Figure 1

(a) The drug administration and study protocol. Eight-week TM treatment affected the (b) oral glucose tolerance, (c) AUC, (d) the serum levels of GHbA1c, (e) the serum levels of PK, and (f) the content of hepatic glycogen in db/db mice compared to db/+ mice. The data were analyzed using post hoc test of Holm-Sidak, and they are expressed as means ± SEMs (). and versus db/⁺ mice; , , and versus nontreated db/db mice. TM: T. melanosporum; AUC: the area under the curve of glucose of oral glucose tolerance; GHbA1c: glycosylated hemoglobin A1c; PK: pyruvate kinase.

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