The Antidiabetic and Antinephritic Activities of Tuber melanosporum via Modulation of Nrf2-Mediated Oxidative Stress in the db/db Mouse
Table 6
Effects of 8-week TM treatment on the bodyweight, plasma glucose, and organ indices of mice.
Week
db/+
db/db
0.1 g/kg Met
0.2 g/kg TM
0.4 g/kg TM
Body weights (g)
1
20.2 ± 0.4
43.2 ± 0.4###
42.9 ± 0.8
43.3 ± 0.8
43.6 ± 0.7
3
21.4 ± 0.4
45.0 ± 0.7###
44.8 ± 0.7
46.5 ± 0.8
44.8 ± 0.7
5
20.9 ± 0.4
48.0 ± 1.1###
43.9 ± 0.9
45.3 ± 1.2
43.6 ± 0.8
7
21.7 ± 0.3
51.7 ± 1.0###
47.5 ± 1.2
50.2 ± 1.3
47.6 ± 0.8
9
21.1 ± 0.7
55.7 ± 0.9###
52.9 ± 0.4
52.8 ± 1.4
49.5 ± 1.2
Plasma glucose (mmol/L)
1
5.6 ± 0.4
19.1 ± 1.4###
19.6 ± 1.2
17.4 ± 0.9
18.8 ± 2.1
3
6.9 ± 0.4
19.6 ± 1.5###
18.8 ± 1.8
17.2 ± 0.9
18.8 ± 2.3
5
6.5 ± 0.3
18.8 ± 1.2###
16.6 ± 1.1
15.8 ± 1.0
16.0 ± 1.5
7
6.6 ± 0.4
21.7 ± 1.2###
16.8 ± 1.2
12.9 ± 1.2
15.1 ± 1.6
9
6.5 ± 0.5
21.3 ± 1.1###
13.8 ± 1.5
14.0 ± 1.2
13.7 ± 1.7
Organ indexes (%)
Spleen
0.32 ± 0.06
0.11 ± 0.01###
0.13 ± 0.01
0.15 ± 0.02
0.17 ± 0.02
Kidney
1.27 ± 0.07
0.70 ± 0.07###
0.79 ± 0.08
0.73 ± 0.07
0.84 ± 0.13
The data were analyzed using a one-way ANOVA and they are expressed as means ± SEMs (). versus db/+ mice; ,, and versus nontreated db/db mice. TM: T. melanosporum.
